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Clenbuterol is a substituted phenylaminoethanol and a long-acting beta-2 adrenergic agonist with sympathomimetic activity. Clenbuterol selectively binds to and activates beta-2 adrenergic receptors in bronchiolar smooth muscle, thereby causing stimulation of adenyl cyclase, the enzyme that catalyzes the conversion of adenosine triphosphate to cyclic-3',5'-adenosine monophosphate (). Clenbuterol overdose can cause myocardial injury and ischemia. The exact mechanism is unclear. It may be due to the inotropic and chronotropic effects that lead to demand ischemia, though there may also be a direct myocardial toxicity [6]. Patients can have acute ischemic patterns on EKG, as well as elevated troponins [6,7]. Over time, repeated episodes of hypoglycemia can lead to hypoglycemia unawareness. The body and brain no longer produce signs and symptoms that warn of a low blood sugar, such as shakiness or irregular heartbeats (palpitations). When this happens, the risk of severe, life-threatening hypoglycemia increases. Hypoglycemia is often defined by a plasma glucose concentration below 70 mg/dL; however, signs and symptoms may not occur until plasma glucose concentrations drop below 55 mg/dL. The symptoms of Whipple's triad have been used to describe hypoglycemia since 1938. Clenbuterol is a β2-adrenoceptor agonist and bronchodilator, formulated to treat various breathing disorders, such as: inflammatory airway disease (IAD) and recurrent airway obstruction (RAO). Overview What is hypoglycemia (low blood sugar)? Hypoglycemia happens when the level of sugar (glucose) in your blood drops below the range that’s healthy for you. It’s also called low blood sugar or low blood glucose. Hypoglycemia is common in people with diabetes, especially Type 1 diabetes
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